ODCs

Cytoscape Web

Click node...

Follicular lymphoma

1 OMIM reference -
4 associated genes
14 signs/symptoms

PROTEIN INTERACTIONS: 1

Wolcott-Rallison syndrome

1 OMIM reference -
1 associated gene
38 signs/symptoms

Follicular lymphoma

Wolcott-Rallison syndrome

BCL2	(UniProt - OMIM)		EIF2AK3	(UniProt - OMIM)
BCL6	(UniProt - OMIM)
HLA-DRB1	(UniProt - OMIM)
IGH	(UniProt)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	BCL6	(0.72)	EIF2AK3

Citations in the biomedical literature:

Follicular lymphoma		Wolcott-Rallison syndrome
	Synonym(s): (no synonyms)		Synonym(s): - Early-onset diabetes mellitus with multiple epiphyseal dysplasia - WRS

	Classification (Orphanet): - Rare hematologic disease - Rare oncologic disease		Classification (Orphanet): - Rare bone disease - Rare developmental defect during embryogenesis - Rare endocrine disease - Rare genetic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Endocrine, nutritional and metabolic diseases -

	Epidemiological data: Class of prevalence: 1-5 / 10 000 Average age onset: adulthood Average age of death: adult Type of inheritance: multigenic/multifactorial		Epidemiological data: Class of prevalence: <1 / 1 000 000 Average age onset: neonatal/infancy Average age of death: - Type of inheritance: autosomal recessive

	External references: 1 OMIM reference - 1 MeSH reference: D008224		External references: 1 OMIM reference - 1 MeSH reference: C536739

Follicular lymphoma		Wolcott-Rallison syndrome
	Very frequent - Fever / chilling - Hematologic / blood / lymphatic cancer - Hyperhidrosis / increased sweating - Lymphadenopathy / polyadenopathies - Weight loss / loss of appetite / break in weight curve / general health alteration Frequent - Asthenia / fatigue / weakness - Mediastinal / hilar adenopathies - Splenomegaly Occasional - Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax - Anomalies of skin, subcutaneous tissue and mucosae - Bone marrow / medullar infiltration - Lymphedema - Meningitis / meningeal syndrome - Structural anomaly of the peritoneum		Very frequent - Autosomal recessive inheritance - Cone epiphyses / epiphysis - Death in infancy - Epiphyseal anomaly - Insulin-independent / type 2 diabetes - Metaphyseal anomaly - Osteoporosis / osteopenia / demineralisation / osteomalacia / rickets - Short stature / dwarfism / nanism Frequent - Abnormal gait - Abnormal hepatic enzymes / transaminases - Acute hepatic failure - Chronic hepatic failure - Delayed bone age - Genu valgum - Hepatomegaly / liver enlargement (excluding storage disease) - Hip dislocation / dysplasia / coxa valga / coxa vara / coxa plana - Immunodeficiency / increased susceptibility to infections / recurrent infections - Intellectual deficit / mental / psychomotor retardation / learning disability - Pelvis anomaly / Narrow / broad iliac wings / pubis abnormality - Platyspondyly - Polynuclear cells / neutrophils anomalies / neutropenia - Short hand / brachydactyly - Short rib cage / thorax - Wide rib cage / thorax Occasional - Agyria / micro / pachy / macrogyria / lissencephaly / gyration / neuronal migration defect - Congenital absence / agenesis / aplasia / hypoplasia of the pancreas - Hepatitis / icterus / cholestasis - Hypoglycemia - Hypothyroidy - Intrauterine growth retardation - Kyphosis - Lordosis - Microcephaly - Mutiple fractures / bone fragility - Pancreatic failure / exocrine pancreas disease - Renal disease / nephropathy - Renal failure - Seizures / epilepsy / absences / spasms / status epilepticus